Vitamin A deficiency

Vitamin A deficiency

Vitamin A rich foods

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What is Vitamin A Deficiency?

Vitamin A deficiency is a surprisingly major health problem worldwide. It is most prevalent in children and expectant women. It is the world leading cause of preventable blindness in children. It compromises immunity and increases the risk of disease and death from severe infections. It is a significant contributor to maternal and child mortality.
According to the World Health Organisation, an estimated 250 million preschool children are Vitamin A deficient and it is likely that in Vitamin A-deficient areas a substantial proportion of pregnant women are Vitamin A-deficient. An estimated 250,000 to 500,000 Vitamin A-deficient children become blind every year, half of them dying within 12 months of losing their sight
For children, lack of Vitamin A causes severe visual impairment and blindness, and significantly increases the risk of severe illness, and even death, from such common childhood infections as diarrhoeal disease and measles. 
For pregnant women in high-risk areas, Vitamin A deficiency occurs especially during the last trimester when demand by both the unborn child and the mother is highest. The mother's deficiency is demonstrated by the high prevalence of night blindness during this period. The impact of Vitamin A deficiency on mother-to-child HIV transmission needs further investigation

Vitamin A has two functions in the body:

  • In the eye to allow for night-vision or for seeing in dim-light circumstances.
  • In the body for regulating the development of various tissues, such as the cells of the skin, and the lining of the lungs and intestines. Vitamin A is important during embryological development, since without the fertilized egg cannot develop into a foetus. 
Overall, it is crucial for a healthy immune system.

Causes of Vitamin A deficiency

  • Primary Vitamin A deficiency is usually caused by prolonged dietary deprivation. 
  • Secondary Vitamin A deficiency tends to happen in:
    • alcoholics
    • people with chronic liver conditions such cirrhosis 
    • people with diseases that affect the intestine's ability to absorb fat. Examples of such diseases are chronic diarrhoea, celiac disease (chronic nutritional disorder), cystic fibrosis, and cholestasis (bile-flow failure or interference). 
    • It may also occur after intestinal surgery. 
    • Vitamin A deficiency is common in prolonged protein-energy malnutrition not only because the diet is deficient but also because Vitamin A storage and transport is defective. 
Normally, the liver stores 80 to 90% of the body's Vitamin A so anything that destroys it (like alcohol abuse) can lead to Vitamin A deficiency.

Symptoms of Vitamin A deficiency

  • Eye symptoms
  • Rough, dry skin 
  • Growth retardation in children 
  • Vulnerability to infections such as urinary tract and respiratory infections 


Night blindness: This is the earliest symptom of Vitamin A deficiency. It is the result of difficulty for the eyes to adjust to dim light. Affected individuals are unable to distinguish images in low levels of illumination. People with night blindness have poor vision in dim light or/darkness, but see normally when adequate light is present.

Vitamin A is needed for the production of rhodopsin, the eye pigment responsible for sensing low light situations. Without this pigment, the eye cannot see well in dim light.


Xeropthalmia: This is a condition where eyes fail to produce tears. Prolonged deficiency results in drying of the conjunctiva (the mucous membrane that lines the inner surface of the eyelids and extends over the forepart of the eyeball). With continued Vitamin A deficiency, the drying extends to the cornea. The cornea eventually shrivels up and becomes ulcerated (keratomalacia). Superficial, foamy gray triangular spots may appear in the white of the eye (Bitot's spots). Finally, inflammation and infection occur in the interior of the eye, resulting in total and irreversible blindness. 
Changes in the skin and the mucous membranes in the respiratory, GI, and urinary tracts can occur. Drying, scaling, and follicular thickening of the skin and respiratory infections can result. Immunity is generally impaired. This results in respiratory, urinary and other infections.
The younger the patient, the more severe are the effects of Vitamin A deficiency. Growth retardation and infections are common among children. Mortality rate can exceed 50% in children with severe Vitamin A deficiency.


When to see a doctor

If you have any of these eye symptoms, go to your doctor who will check your retinol (Vitamin A) levels and institute the necessary management.

Prevention and treatment

Prevention and Treatment

  • Eat diet rich in Vitamin A. Liver is the richest animal source. In plants it is in the form of carotenoids like beta-carotene, best found in yellow and dark green crops. (see table).
  • Food fortification: can be done with wheat, milk or even sugar but this is a costly process. Margarine and oil are the ideal food vehicles for Vitamin A fortification. 
  • Supplements: this is the approach taken by most developing countries. Some have incorporated Vitamin A supplementation to their immunization schedule. Giving the supplements up to five years of life. It is usually given in oral form. It is affordable and readily acceptable amongst most communities. 



Remember a Vitamin A deficiency in lactating mothers will produce breast milk with low levels of Vitamin A. Maternal supplementation benefits both mother and breast-fed infant: high dose Vitamin A supplementation of the breast-feeding mother in the first month after delivery can provide the breast-fed infant with an appropriate amount of Vitamin A through breast milk. However, high-dose supplementation of pregnant women should be avoided because it can cause miscarriage and birth defects. 


How much Vitamin A do you need?

Recommended Dietary Allowance (RDA) for Vitamin A as Preformed Vitamin A (Retinol Activity Equivalents) 


Life Stage Age Males: mcg/day (IU/day) Females: mcg/day (IU/day) 
Infants 0-6 months 400 (1,333 IU)400 (1,333 IU)
Infants 7-12 months 500 (1,667 IU) 500 (1,667 IU) 
Children 1-3 years 300 (1,000 IU)300 (1,000 IU)
Children 4-8 years 400 (1,333 IU)400 (1,333 IU)
Children 9-13 years 600 (2,000 IU) 600 (2,000 IU) 
Adolescents 14-18 years 900 (3,000 IU) 700 (2,333 IU) 
Adults 19 years and older 900 (3,000 IU) 700 (2,333 IU) 
Pregnancy 18 years and
750 (2,500 IU) 
Pregnancy19 years and older770 (2,567 IU)
Breast-feeding 18 years and
1,200 (4,000 IU) 
Breast-feeding 18 years and 
1,200 (4,000 IU) 
Breast-feeding 19 years and older -1,300 (4,333 IU)


Vitamin A rich foods

FoodServingVitamin A,
Vitamin A, IU
Cod liver oil1 teaspoon1,350 mcg 4,500 IU 
1 serving150-230 mcg500-767 IU
Egg1 large91 mcg 303 IU 
Butter1 tablespoon97 mcg 323 IU 
Whole milk1 cup (8 fl oz.)68 mcg 227 IU 
2% fat milk
(vitamin A 
1 cup (8 fl oz)134 mcg447 IU
Nonfat milk
(vitamin A 
1 cup (8 fl oz.)149 mcg497 IU
Sweet potato, 
1/2 cup,
555 mcg 1,848 IU 
Sweet potato, 
1/2 cup961 mcg 3,203 IU 
Pumpkin, canned1/2 cup953 mcg 3,177 IU 
Carrot (raw)1/2 cup, chopped538 mcg 1,793 IU 
Cantaloupe1/2 medium melon467 mcg 1,555 IU 
Mango1 fruit79 mcg 263 IU 
Spinach1/2 cup, cooked472 mcg 1,572 IU 
Broccoli1/2 cup, cooked60 mcg 200 IU 
Kale1/2 cup, cooked443 mcg 1,475 IU 
Collards1/2 cup, cooked386 mcg 1,285 IU 
Squash, butternut 1/2 cup, cooked572 mcg 1,907 IU 




The treatment for Vitamin A Deficiency related problems involves giving high dose Vitamin A (usually available as retinyl palmitate) either orally or through injection.
In children with complicated measles, Vitamin A can shorten the duration of the disorder and reduce the severity of symptoms and risk of death.



The prognosis for correcting night blindness is excellent. 
Xerophthalamia can be corrected with Vitamin A therapy. Ulcerations, tissue death, and total blindness, caused by severe Vitamin A deficiency, cannot be treated with Vitamin A.


Review Process

1: First edition: Dr. Mukuhi Nganga, 2009
2: Review and update: Alice Ndong February 2012

Information Source Links

  • Human Vitamins requirement; Report of Joint FAO - WHO expert Consultation 2002 ( Bangkok Thailand)
  • Balch Phylis A. and and Balch James F.; Prescription fro Nutritional healing, 3rd Edition.
  • Lee V, Ahmed F, Wada S, et al. (2008): Extent of vitamin A deficiency among rural pregnant women in Bangladesh. PUBLIC HEALTH NUTR. Jun 12 2008;1-6.
  • D'Souza RM, D'Souza R (2002):. Vitamin A for treating measles in children. COCHRANE DATABASE SYST REV;(1):CD001479.


Last updated on:
Wed, 10/02/2019 - 08:49